In this week's Editor's Pick, Jayaraj Rajagopal and colleagues, describe their findings studying the ability of mouse airway epithelia to dedifferentiate and contribute stem cells for the adult airway. This study may be part of a more generalizable mechanism whereby differentiated cells may dedifferentiate and contribute to the regenerative ability of different organs.
November 17-November 22 2013
Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway.Cell Stem Cell13, 564-76.(2013).
Dedifferentiation of committed epithelial cells into stem cells in vivo.Nature503, 218-23.(2013).